Corealis Pharma Expands GMP Granulation Capabilities with the Gerteis Mini-Polygran® 150/30/3 Roller Compactor

Advancing Granulation with Science-Driven Development

Granulation is an increasingly important manufacturing approach for oral solid dosage products, particularly when working with moisture-sensitive, heat-sensitive, or difficult-to-process compounds. However, developing a robust roller compaction process requires a deep understanding of material behavior while making the most of limited API supplies.

Corealis Pharma already offers established roller compaction capabilities with the Vector TFC-Micro and the Vector TFC-220, supporting GMP manufacturing programs.  Now, we have expanded to further strengthen formulation development capabilities with the addition of the new Gerteis Mini-Polygran® 150/30/3 Roller Compactor, a fully qualified GMP system now available for client projects.

This investment enhances Corealis' ability to support granulation programs from early formulation development through clinical manufacturing.

Optimized for Early Development

The Gerteis Mini-Polygran is specifically designed for pharmaceutical roller compaction studies using minimal quantities of API.

Its continuous compaction process enables formulation scientists to evaluate critical process parameters while producing representative ribbons and granules for downstream processing and characterization. This allows valuable process knowledge to be established early, helping teams make informed development decisions before larger API quantities are available.

Combining Technology with Scientific Expertise

By integrating the Gerteis Mini-Polygran with Corealis' formulation development expertise, in-house analytical services, and Solid Fraction Ribbon characterization capabilities, clients gain a comprehensive understanding of how process parameters influence ribbon quality, granule properties, and final dosage form performance.

Corealis supports clients through:

• Formulation screening using minimal API 

• Roller compaction process optimization 

• Solid Fraction Ribbon characterization 

• Granule property evaluation 

• Tabletability assessments 

• Development of scalable process design spaces 

• Process transfer and scale-up support 

  
  

This integrated approach enables more informed development decisions while reducing technical risk throughout the product lifecycle.

Built for GMP Development

The Gerteis Mini-Polygran has been fully qualified within Corealis' GMP environment and is available to support client development programs.

Whether evaluating granulation for the first time or optimizing an existing formulation, clients benefit from a platform designed to generate meaningful development data while preserving valuable API and building a strong foundation for successful clinical manufacturing.

Partner with Corealis

From formulation development and analytical characterization to GMP clinical manufacturing, Corealis delivers integrated oral solid dosage solutions designed to accelerate development and reduce risk.

Contact our team to learn how our GMP roller compaction capabilities can support your next development program.